Deputy Superintendent of Police (DSP) Mumtaz Shah was shot dead in the Malir Cantt area of the metropolis early Saturday.
As per details, DSP Mumtaz Shah was on his way to the office when two unidentified gunmen on motorcycles opened fire on his car.
The DSP was shot three times in the head and chest before he died on the spot. The attackers reportedly used 9mm weapons.
Police have arrived at the scene and launched investigation into the incident.
Karachi, which is Pakistan's largest city, is suffering from an unprecedented wave of killings and kidnappings blamed on militants, criminals, and ethnic and political tensions.
Gang wars fed by ethnic and political bitterness, drugs and the Taliban, have created a culture of impunity in the city of 18 million, and the past two years have seen record death tolls.
In the first six months of 2013, 1,726 people were killed compared with a previous high of 1,215 in the same period last year, according to the Human Rights Commission of Pakistan. Shah was appointed at Landhi prison.
Tension prevailed in the area after the incident.