At least six people were killed and several others injured when an unmanned US drone fired two missiles into an alleged militants compounds in North Waziristan.
Official sources said that the U.S. unmanned plane fired two missiles at a compound in the Ghulam Khan area of North Waziristan, a restive tribal region bordering Afghanistan.
Ghulam Khan is also the third most important border crossing point between the two countries after Chaman and Torkham.
The missiles completely destroyed the building and killed four people inside. Local people rushed to site and took out the bodies from the rubble of the building.
There were no reports about the identities of the killed people yet.
Thursday night's attack in North Waziristan is the 19th of its kind in Pakistan since the start of this year that have killed at least 120 people so far.
US drone attacks are deeply unpopular in Pakistan, but Washington views them as a vital tool in the fight against Taliban and Al-Qaeda militants in the lawless tribal areas along the border with Afghanistan.
Meanwhile, Pakistan condemned Friday a latest American drone strike in the country's tribal region and warned that such strikes set"dangerous precedents in the inter- state relations."
An American spy aircraft rained missiles into North Waziristan tribal region and killed at least five people early Friday, security officials said.
The U.S. unmanned drone fired two missiles at a compound in Ghulam Khan area, close to the Afghan border, tribesmen said. They said the house was destroyed in the strike.
"The government of Pakistan strongly condemns the U.S. drone strike that took place in Ghulam Khan area of North Waziristan on the early morning of Sept. 6," the Foreign Ministry said.
"These unilateral strikes are a violation of Pakistan's sovereignty and territorial integrity. Pakistan has repeatedly emphasized the importance of bringing an immediate end to drone strikes," a Foreign Ministry statement said.
It said the government of Pakistan has consistently maintained that drone strikes are counter-productive, entail loss of innocent civilian lives and have human rights and humanitarian implications. "These drone strikes have a negative impact on the mutual desire of both countries to forge a cordial and cooperative relationship and to ensure peace and stability in the region,"the Foreign Ministry said.
U.S. Secretary of State John Kerry suggested last week that drone strikes targeting Taliban and al-Qaida operatives in Pakistan could end"very soon"as the threat of militancy recedes.
Reports suggest that Friday's attack was the 19th in Pakistan this year. Nearly 120 people have been killed in such attacks by far.