At least six people were killed in a drone strike in Mach Magai area of Loe Shalman near Khyber Agency on Saturday.
According to political administration, two missiles were fired while a boat in River Kabul was targeted in the strike.
Six people were killed while two others injured in the drone attack, the administration added.
The injured identified as Hamid and Shabir were taken to Landikotal Hospital.
This is the first US drone strike in Loe Shalman area.
The last drone strike was carried out in Hangu district of Khyber Pakhtunkhwa that killed six people.