A US drone killed at least four people in a missile strike Saturday targeting a compound in northwest Pakistan's tribal belt, local security officials said.
The attack took place in the village of Heso Khel around 35 kilometres (21 miles) east of Miranshah, the main town in North Waziristan.
"At least four suspected militants have been killed and the compound has been completely destroyed," a local security official in Miranshah told AFP.
A second security official in Peshawar, capital of Khyber Pakhtunkhwa province, confirmed the attack but said the death toll may rise.
Saturday's drone strike in North Waziristan is the 18th of its kind in Pakistan in 2013, which has left at least 116 people dead so far this year.
Pakistan will formally lodge a protest against U.S. drone attacks in the UN General Assembly session next month, Adviser on Foreign Affairs Sartaj Aziz said Friday.
In a policy statement to the National Assembly, he said the U.S. drone attacks violate Pakistan's sovereignty and international laws.
"A breakthrough is expected on the issue of U.S. drone strikes in the coming months," he said, without elaborating.
The U.S. said the drone strikes target militants accused of crossing the border into Afghanistan to launch attacks on foreign and Afghan forces.
Aziz said that Pakistani leaders would urge U.S. authorities to stop drone strikes as they were counterproductive.