A US drone raid targeting a compound and a vehicle in ShnaKhura area near Miranshah on Tuesday killed at least three persons in North Waziristan.
Two US drones fired four missiles on a vehicle in Shnakhura village, 10 kilometres from Miranshah.
"We have received confirmed reports that three militants have been killed in the drone strike on a vehicle. However, the identities of the militants are not yet clear," a senior security official told AFP in Peshawar.
Another official in Miranshah said a compound near the vehicle was "badly damaged and engulfed in flames" in the strike.
Separate but unconfirmed reports suggested more than three militants may have been killed.
"We suspect that the dead militants could be up to six. There are also reports that two were injured," a security official in Miranshah told AFP on condition of anonymity because he was not authorised to speak to the media.