SHANGHAI (AFP) - Big-serving Jo-Wilfried Tsonga was sent crashing out of the Shanghai Masters on Wednesday by Japan's Kei Nishikori but untroubled top seed Rafael Nadal eased through to the third round. Tsonga, the fourth seed, who lost 7-6 (7/1), 4-6, 4-6, appeared to be on his way to a straightforward victory when he stepped up the intensity of his game to seal the first set tie-break with the loss of just one point. But world number 47 Nishikori, who needed courtside treatment on his back, broke twice in the second set, levelling the match when the Frenchman netted with a forehand. Nishikori, who has a poor record against top 10 players, produced two more breaks in the deciding set, taking advantage of an error-strewn performance by Tsonga and sealing the win on his third match point. The defeat puts a serious dent in the Frenchman's bid to reach next month's ATP World Tour Finals. He came into the Shanghai Masters in eighth place in the race to reach the showpiece, featuring the top eight players of the year. Referring to his chances of reaching the year-end ATP tournament in London, he said: "At the moment I'm confident. I will take some rest and then I will come back to qualify." In his first match of the tournament after a first-round bye given to the top eight seeds, world number two Nadal, bidding for his 20th Masters title, beat fellow Spaniard Guillermo Garcia-Lopez 6-3, 6-2. Speaking after his win, Nadal, who lost to Garcia-Lopez in Bangkok last year, said: "It was a little bit in my mind today in the break points, that's the truth. And for the rest, sure, I am happy to be in the second round. Second seed Andy Murray had a walkover into the third round after Dmitry Tursunov of Russia withdrew from their second round match with a right thigh injury. Spain's third seed David Ferrer came out on top 7-5, 7-6 (9/7) in his second round clash with Canada's Milos Raonic, and Czech player Tomas Berdych beat compatriot Radek Stepanek 6-4, 6-3. Earlier, Juan Carlos Ferrero came from a set down in an all-Spanish tie to oust 16th seed Fernando Verdasco 4-6, 6-3, 6-2, breaking six times during a match lasting a little over two hours. There was also a win for 12th seed Alexandr Dolgopolov of Ukraine, who overcame Spain's Albert Ramos 5-7, 6-3, 6-2. Austria's 14th seed Jurgen Melzer lost in three sets to Colombia's Santiago Giraldo while Australia's Matthew Ebden beat America's Ryan Harrison in straight sets.